It depends how far from the Earth do you want to go?? Just off-Earth or to another planet. With the latter, cos of the time differential and wanting to get there in your own life-time then you would need a time machine or access to jumpgates.
If you couldn't cheat and use only Earth technology, even from the future, you would be limited.
I'm going to be awkward and choose fiction rather than film or TV which shows none of the problems with sewage and boredom,
If you wanted room to wander in transit, then I would choose one of those mile long spaceships that Cordwainer Smith had in his Instrumentality stories or the equally long spaceships using distorter technology in Van Vogt's stories which also has the means to get you off-ship quickly in an emergency.